Testosterone 101

Everything you need to know about testosterone, backed by the latest research. We turn complex topics like diagnosis, dosing, delivery methods, and lab results into simple, practical insights. Understand TRT benefits and risks, maintain estradiol balance, and spot drug interactions - all grounded in evidence, not hype.

How to measure testosterone accurately: The blood tests that actually matter

How to measure testosterone accurately: The blood tests that actually matter

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 10, 2025 · 14 min read

You measure testosterone most accurately with a morning blood test that reports total testosterone and free testosterone, ideally processed by a CLIA certified laboratory. The details matter, because timing, test type, and follow up labs can be the difference between useful data and a false alarm. “If you want to know how to measure testosterone ...

Does testosterone increase metabolism in men?

Does testosterone increase metabolism in men?

Dr. Susan Carter, MD avatar
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 09, 2025 · 13 min read

In men with confirmed testosterone deficiency, testosterone replacement can modestly increase metabolic rate over 6 to 12 months, largely by adding lean muscle (which raises basal metabolic rate) and reducing visceral fat. The biggest payoff shows up when strength training, protein intake, and sleep are dialed in, and men with normal levels usually see little ...

What is sex hormone binding globulin? How SHBG levels shape testosterone in men

What is sex hormone binding globulin? How SHBG levels shape testosterone in men

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 09, 2025 · 14 min read

Sex hormone binding globulin is a liver made protein that binds testosterone and other sex hormones, and SHBG levels help predict how much testosterone is actually available to your tissues. If you have low testosterone symptoms but “normal” total testosterone, SHBG is often the missing piece that explains why you still feel off. “Most guys ...

Semaglutide and testosterone: The science of combining therapies for men

Semaglutide and testosterone: The science of combining therapies for men

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 08, 2025 · 11 min read

In men with obesity (BMI over 30) and low testosterone, combining semaglutide with testosterone therapy can promote fat loss while helping preserve lean muscle by reducing adipose-driven aromatase conversion of testosterone to estradiol and supporting anabolic metabolism. Instead of treating weight and hormones as separate problems, this paired approach targets the feedback loop where visceral ...

Normal BMI band for men: What research says and why

Normal BMI band for men: What research says and why

Dr. Susan Carter, MD avatar
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 07, 2025 · 14 min read

A “normal” BMI is 18.5 to 24.9 kg/m². It is a population screening tool and does not directly measure body fat, muscle mass, or visceral fat, so use it as a starting point. Pair BMI with waist circumference, body composition, and a few core metabolic labs to decide what to change and what to track. ...

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