Testosterone 101

Everything you need to know about testosterone, backed by the latest research. We turn complex topics like diagnosis, dosing, delivery methods, and lab results into simple, practical insights. Understand TRT benefits and risks, maintain estradiol balance, and spot drug interactions - all grounded in evidence, not hype.

7 low testosterone symptoms: Get small daily joys back!

7 low testosterone symptoms: Get small daily joys back!

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Oct 23, 2025 · 14 min read

Clinically significant testosterone deficiency is diagnosed only when ongoing symptoms like fatigue, low libido, and “losing your edge” occur alongside consistently low early‑morning testosterone on repeat blood tests (the AUA/EAU “two‑key” rule). Because these signals can mimic stress or normal aging, here’s how to recognize the hormone-driven pattern and what to do next to get ...

5 testosterone side effects you must be aware of

5 testosterone side effects you must be aware of

Dr. Susan Carter, MD avatar
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Oct 14, 2025 · 15 min read

Testosterone replacement commonly causes a 2–5 mmHg rise in blood pressure, can thicken blood via erythrocytosis (hematocrit may climb to ≥54%), may suppress sperm production and fertility, can increase oily skin/acne, and can worsen obstructive sleep apnea. Tracking blood pressure, hematocrit, and symptoms from day one helps you and your clinician adjust dose or formulation ...

Enclomiphene: Double testosterone without injections

Enclomiphene: Double testosterone without injections

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Oct 12, 2025 · 12 min read

In randomized trials of men with functional hypogonadism, daily enclomiphene (a SERM) blocks estrogen feedback in the hypothalamus and pituitary to raise LH/FSH and increase morning testosterone into or near the normal range—sometimes roughly doubling very low baseline levels—while sperm counts stayed largely stable. Here’s who is most likely to benefit, what to monitor, and ...

Testosterone replacement therapy costs: Factors and savings tips

Testosterone replacement therapy costs: Factors and savings tips

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Aug 26, 2025 · 14 min read

TRT commonly costs about $60–$150 per month for generic injections when insurance covers key components, but can run $400–$1,000 per month for branded gels or pellets when you’re paying out of pocket. The gap is driven by labs, visit fees, and drug delivery choice—and knowing where to trim (without skipping guideline basics like two low ...

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