Posts in Testosterone 101

Everything you need to know about testosterone, backed by the latest research. We turn complex topics like diagnosis, dosing, delivery methods, and lab results into simple, practical insights. Understand TRT benefits and risks, maintain estradiol balance, and spot drug interactions - all grounded in evidence, not hype.

Top 3 ways to increase testosterone naturally

Top 3 ways to increase testosterone naturally

Alexander Grant, MD, PhD: Urologist & Men’s health advocate avatar
Alexander Grant, MD, PhD: Urologist & Men’s health advocate
Oct 30, 2025

Losing about ten percent of body weight can raise testosterone roughly 85 ng per dL. A fifteen percent loss can raise it around 250 ng per dL. Treating sleep apnea and guarding the second half of the night also supports testosterone [1]. Incorporating regular exercise, especially resistance training, can further enhance testosterone levels, complementing the […]

Estrogen in men: Low Estradiol can ruin your TRT therapy

Estrogen in men: Low Estradiol can ruin your TRT therapy

Susan Carter, MD: Endocrinologist & Longevity expert avatar
Susan Carter, MD: Endocrinologist & Longevity expert
Oct 26, 2025

Estradiol supports desire, sexual function, and bone health in men. Levels that are too low can crash libido and weaken bones. Many men on testosterone feel better when estradiol is in a middle range, not crushed to zero. Be careful with any clinic that gives you an aromatase blocker by default with no symptoms. “Men […]

7 low testosterone symptoms: Get small daily joys back!

7 low testosterone symptoms: Get small daily joys back!

Alexander Grant, MD, PhD: Urologist & Men’s health advocate avatar
Alexander Grant, MD, PhD: Urologist & Men’s health advocate
Oct 23, 2025

Low testosterone can dull energy, drive, and mood. Treating a true deficiency often helps men re-engage with work, family, and hobbies. “Men often look only at libido. The real low testosterone symptoms: fewer morning erections, low drive, fatigue, weight gain, and slower recovery. When testosterone is truly low, treating it can bring daily life back […]

Testosterone Сypionate: Relief you can feel, but what about fertility?

Testosterone Сypionate: Relief you can feel, but what about fertility?

Alexander Grant, MD, PhD: Urologist & Men’s health advocate avatar
Alexander Grant, MD, PhD: Urologist & Men’s health advocate
Oct 17, 2025

TRT injections work when dosed in physiologic ranges like about 50 mg twice weekly, yet they also suppress LH and FSH and can drop sperm counts. Know how to dose, test, and protect fertility. “You can feel better on injections fast, but dosing and lab follow up matter. Keep levels steady, watch hematocrit and PSA, […]

5 testosterone side effects you must be aware of

5 testosterone side effects you must be aware of

Susan Carter, MD: Endocrinologist & Longevity expert avatar
Susan Carter, MD: Endocrinologist & Longevity expert
Oct 14, 2025

Testosterone replacement therapy is treatment that raises low testosterone into a healthy range to relieve symptoms such as low energy, libido loss, and decreased strength [1,2]. The upside is real, but so are a few predictable testosterone side effects, led by blood pressure increases and red-cell elevation that can thicken the blood [1,3–5]. “Side effects […]