Understanding testosterone replacement therapy side effects and management
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Aug 23, 2025 · 14 min read
In men with confirmed hypogonadism (often total testosterone
Testosterone 101
Everything you need to know about testosterone, backed by the latest research. We turn complex topics like diagnosis, dosing, delivery methods, and lab results into simple, practical insights. Understand TRT benefits and risks, maintain estradiol balance, and spot drug interactions - all grounded in evidence, not hype.
Unexpected effects of testosterone therapy you should know
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Aug 23, 2025 · 15 min read
Testosterone therapy can cause “unexpected” side effects beyond libido and muscle gains, including bone-marrow–driven rises in hemoglobin/hematocrit that can reach erythrocytosis when hematocrit exceeds ~54%, along with water retention, acne, mood changes, and reduced fertility. Here’s what to monitor, why these effects happen, and how to manage them safely with your clinician. “Testosterone can be ...
Choosing the best testosterone replacement therapy clinic for you
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Aug 08, 2025 · 14 min read
The best TRT clinic is one that confirms true hypogonadism with both symptoms and repeat labs (often total testosterone <350 ng/dL or free testosterone <100 pg/mL) and then matches the dose, delivery method, and monitoring plan to your health risks. Here’s how to compare injections, gels, and other options—and spot a clinic that treats the ...
What you need to know about testosterone replacement therapy risks
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Aug 07, 2025 · 14 min read
In men with confirmed hypogonadism (total testosterone below ~350 ng/dL or free testosterone below ~100 pg/mL), properly monitored TRT hasn’t shown a major rise in heart attack or stroke risk in recent trials, but it can increase hematocrit by stimulating red blood cell production and may worsen prostate symptoms or suppress fertility over time. Here’s ...