Testosterone 101

Everything you need to know about testosterone, backed by the latest research. We turn complex topics like diagnosis, dosing, delivery methods, and lab results into simple, practical insights. Understand TRT benefits and risks, maintain estradiol balance, and spot drug interactions - all grounded in evidence, not hype.

Does alcohol cause inflammation? What men need to know about the immune response

Does alcohol cause inflammation? What men need to know about the immune response

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Jan 04, 2026 · 11 min read

Alcohol causes systemic, dose-dependent inflammation by producing acetaldehyde and activating liver immune cells (Kupffer cells) to release pro-inflammatory cytokines such as TNF-α and IL-6, while also weakening the gut barrier so bacterial toxins can enter the bloodstream. That immune “alarm” can keep firing long after the buzz fades. It can affect blood vessels, testosterone production, ...

What is biohacking? A doctor’s guide for men who want measurable health gains

What is biohacking? A doctor’s guide for men who want measurable health gains

Dr. Susan Carter, MD avatar
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Jan 03, 2026 · 11 min read

Biohacking is the practice of using science, self tracking, and targeted lifestyle changes to improve healthspan and lifespan. For men, the best biohacking focuses on sleep, body composition, cardiometabolic health, stress hormones, and lab guided decisions you can actually sustain. “The best biohacking is not extreme. It is repeatable. If you can measure it, recover ...

Is a midlife crisis in men real? What midlife crisis men can do next

Is a midlife crisis in men real? What midlife crisis men can do next

Dr. Jonathan Pierce, PhD avatar
Dr. Jonathan Pierce, PhD: Clinical Psychologist & Neuroscience Specialist
Dec 31, 2025 · 10 min read

A midlife crisis in men is not an official medical diagnosis, but the stress, mood shifts, and health changes many men feel in their 40s and 50s can be very real and very disruptive. The good news is that the “crisis” phase is often a signal to reassess sleep, hormones, purpose, and relationships, then rebuild ...

Peptides vs TRT: Which option fits your symptoms, labs, and goals?

Peptides vs TRT: Which option fits your symptoms, labs, and goals?

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 31, 2025 · 11 min read

Peptides vs TRT is not a direct swap because TRT replaces testosterone while growth hormone secretagogue peptides stimulate your own growth hormone release. The right choice depends on your symptoms, your lab pattern, and whether priorities like libido, sleep, recovery, and fertility are on the table. “In clinic, the biggest mistake I see with peptides ...

Seasonal affective disorder hormones: How to tell SAD from low testosterone in men

Seasonal affective disorder hormones: How to tell SAD from low testosterone in men

Dr. Susan Carter, MD avatar
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 29, 2025 · 13 min read

SAD usually follows a repeatable fall-to-winter pattern and improves in spring, while low testosterone is more likely when symptoms are persistent, come with libido or erection changes, and are confirmed on repeat morning blood tests. If your symptoms do not cleanly follow the calendar, or they come with sexual or sleep changes, it is time ...

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