Testosterone 101 | Veedma's evidence-based men's health articles

Does alcohol cause inflammation? What men need to know about the immune response

Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate

Jan 04, 2026 · 10 min read

Alcohol causes systemic, dose-dependent inflammation by producing acetaldehyde and activating liver immune cells (Kupffer cells) to release pro-inflammatory cytokines such as TNF-α and IL-6, while also weakening the gut barrier so bacterial toxins can enter the bloodstream. That immune “alarm” can keep firing long after the buzz fades—affecting blood vessels, testosterone production, and sexual function. ...

What is biohacking? The science of optimizing male biology

Dr. Susan Carter, MD: Endocrinologist & Longevity Expert

Jan 03, 2026 · 10 min read

Biohacking is a data-driven approach to improving physiology by measuring key biomarkers (such as glucose, cortisol, and testosterone), changing lifestyle or environmental inputs, and re-testing using a “measure, modify, measure” loop. Here’s how mechanisms like epigenetic regulation and hormesis can help counter modern stressors and extend healthspan. “Biohacking is often marketed as a shortcut, but ...

Is the male midlife crisis real? The science behind the slump

Dr. Jonathan Pierce, PhD: Clinical Psychologist & Neuroscience Specialist

Dec 31, 2025 · 9 min read

A male “midlife crisis” isn’t a DSM-5 diagnosis, but the midlife slump is real: large studies show life satisfaction typically bottoms out around ages 47–48, often colliding with age-related testosterone decline and peak life stress. Here’s what’s happening in the brain and body—and how to navigate the shift with a strategy, not willpower. “We often ...

Peptides vs TRT: Which therapy optimizes male performance and longevity?

Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate

Dec 31, 2025 · 10 min read

TRT best optimizes male performance when a man has clinically low testosterone (levels decline about 1% per year after age 30) because it replaces missing androgen directly, while growth-hormone secretagogue peptides target recovery and tissue repair by stimulating the pituitary to pulse more of its own HGH—so neither is universally “better” for longevity. Here’s how ...

Seasonal affective disorder or hormones? A men’s guide to winter mood, testosterone, and sleep

Dr. Susan Carter, MD: Endocrinologist & Longevity Expert

Dec 29, 2025 · 12 min read

In men, winter “low mood” can be true seasonal affective disorder (a recurrent depressive pattern that starts in late fall, peaks in winter, and eases as daylight returns) or a look‑alike driven by physiology—less morning light can delay your circadian rhythm and prolong melatonin, while testosterone, cortisol, and thyroid shifts can produce the same fatigue ...