XY Files Blog

Evidence-based articles on testosterone, men's health, fitness, longevity, and sexual health.

9 foods that fight hot flashes in men and what to avoid

9 foods that fight hot flashes in men and what to avoid

Alexander Grant, MD, PhD avatar
Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Jan 07, 2026 · 12 min read

Certain foods and diet patterns can help reduce hot flash frequency and intensity in men, especially when episodes are linked to hormone shifts, blood sugar swings, or inflammation. The best approach is not one “miracle food,” but a repeatable way of eating that keeps your internal thermostat more stable. “In men, hot flashes are often ...

Mediterranean diet snacks to optimize testosterone and heart health in men

Mediterranean diet snacks to optimize testosterone and heart health in men

Susan Carter, MD avatar
Susan Carter, MD: Endocrinologist & Longevity Expert
Jan 07, 2026 · 10 min read

Mediterranean-style snacks built around monounsaturated fats, polyphenols, and protein (such as walnuts, olives, and plain Greek yogurt) can support testosterone and heart health in men by reducing sharp post-snack glucose and insulin spikes and lowering chronic inflammation that can suppress testosterone production and damage endothelial function. Here’s how to use between-meal “fuel” to keep energy ...

Sea moss benefits for men: Fact checking the fertility superfood

Sea moss benefits for men: Fact checking the fertility superfood

Alexander Grant, MD, PhD avatar
Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Jan 06, 2026 · 10 min read

Sea moss has limited direct evidence for boosting testosterone or male fertility in men, but its iodine content may support thyroid function in people who are iodine-deficient. Here’s what the data supports. It also shows where the “fertility superfood” marketing goes beyond the science. “Sea moss is nutrient-dense, but it is not a magic switch ...

Does lifting weights burn fat? The science-backed answer for men who want visible results

Does lifting weights burn fat? The science-backed answer for men who want visible results

Bruno Rodriguez, DPT, CSCS avatar
Bruno Rodriguez, DPT, CSCS: Strength, Recovery, and Physical Therapy Expert
Jan 05, 2026 · 10 min read

Lifting weights can support fat loss by building and preserving muscle, which helps maintain a higher resting metabolic rate and improves body composition over weeks and months. Here’s how to set up your training and tracking so the mirror changes even when your workout isn’t “burning fat” in the moment. “If you’re asking ‘does lifting ...

Does alcohol cause inflammation? What men need to know about the immune response

Does alcohol cause inflammation? What men need to know about the immune response

Alexander Grant, MD, PhD avatar
Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Jan 04, 2026 · 11 min read

Alcohol causes systemic, dose-dependent inflammation by producing acetaldehyde and activating liver immune cells (Kupffer cells) to release pro-inflammatory cytokines such as TNF-α and IL-6, while also weakening the gut barrier so bacterial toxins can enter the bloodstream. That immune “alarm” can keep firing long after the buzz fades. It can affect blood vessels, testosterone production, ...

What is biohacking? A doctor’s guide for men who want measurable health gains

What is biohacking? A doctor’s guide for men who want measurable health gains

Susan Carter, MD avatar
Susan Carter, MD: Endocrinologist & Longevity Expert
Jan 03, 2026 · 11 min read

Biohacking is the practice of using science, self tracking, and targeted lifestyle changes to improve healthspan and lifespan. For men, the best biohacking focuses on sleep, body composition, cardiometabolic health, stress hormones, and lab guided decisions you can actually sustain. “The best biohacking is not extreme. It is repeatable. If you can measure it, recover ...

Body recomposition for men: How to lose fat and gain muscle at the same time

Body recomposition for men: How to lose fat and gain muscle at the same time

Bruno Rodriguez, DPT, CSCS avatar
Bruno Rodriguez, DPT, CSCS: Strength, Recovery, and Physical Therapy Expert
Jan 02, 2026 · 11 min read

Body recomposition is a training and nutrition approach that reduces fat mass while increasing muscle mass. If you do it right, your waist can shrink and your strength can climb even when the scale barely moves. “The men who succeed with body recomposition stop chasing a single number on the scale. They measure strength, waist, ...

Does creatine cause erectile dysfunction? What the evidence says for men

Does creatine cause erectile dysfunction? What the evidence says for men

Alexander Grant, MD, PhD avatar
Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Jan 01, 2026 · 10 min read

No, creatine does not cause erectile dysfunction in men based on the current clinical evidence. The more important story is why the rumor started, what actually drives ED, and how to use creatine safely while protecting sexual performance. “When men ask me, ‘does creatine cause erectile dysfunction,’ my answer is no. In the medical literature ...

Is a midlife crisis in men real? What midlife crisis men can do next

Is a midlife crisis in men real? What midlife crisis men can do next

Jonathan Pierce, PhD avatar
Jonathan Pierce, PhD: Clinical Psychologist & Neuroscience Specialist
Dec 31, 2025 · 10 min read

A midlife crisis in men is not an official medical diagnosis, but the stress, mood shifts, and health changes many men feel in their 40s and 50s can be very real and very disruptive. The good news is that the “crisis” phase is often a signal to reassess sleep, hormones, purpose, and relationships, then rebuild ...

Peptides vs TRT: Which option fits your symptoms, labs, and goals?

Peptides vs TRT: Which option fits your symptoms, labs, and goals?

Alexander Grant, MD, PhD avatar
Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 31, 2025 · 11 min read

Peptides vs TRT is not a direct swap because TRT replaces testosterone while growth hormone secretagogue peptides stimulate your own growth hormone release. The right choice depends on your symptoms, your lab pattern, and whether priorities like libido, sleep, recovery, and fertility are on the table. “In clinic, the biggest mistake I see with peptides ...

Joe Rogan’s Onnit creatine (5 g): What science shows

Joe Rogan’s Onnit creatine (5 g): What science shows

Bruno Rodriguez, DPT, CSCS avatar
Bruno Rodriguez, DPT, CSCS: Strength, Recovery, and Physical Therapy Expert
Dec 30, 2025 · 13 min read

Onnit creatine is standard creatine monohydrate, and 5 g per day is a well supported maintenance dose for most men who want better repeated high intensity performance and more lean mass when paired with resistance training.[1] If you’re asking what creatine Joe Rogan uses, the consistent, evidence-based answer is creatine monohydrate—typically taken as about 3 ...

Can you build muscle in a calorie deficit? The science based approach for men

Can you build muscle in a calorie deficit? The science based approach for men

Bruno Rodriguez, DPT, CSCS avatar
Bruno Rodriguez, DPT, CSCS: Strength, Recovery, and Physical Therapy Expert
Dec 29, 2025 · 12 min read

Yes, you can build muscle in a calorie deficit, especially if your training is progressive, your protein intake is high, and your calorie cut is modest. The hard part is doing it without sacrificing strength, sleep, and recovery, which is where most men go wrong. “Most guys do not fail body recomposition because they lack ...

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