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All the latest articles from our medical experts on testosterone, men's health, and longevity.

Enclomiphene: Double testosterone without injections

Enclomiphene: Double testosterone without injections

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Oct 12, 2025 · 13 min read

In randomized trials of men with functional hypogonadism, daily enclomiphene (a SERM) blocks estrogen feedback in the hypothalamus and pituitary to raise LH and FSH. This can increase morning testosterone into or near the normal range, and in some men with very low baseline levels it may roughly double testosterone on labs while sperm counts ...

Low testosterone: 10 quiet signs beyond libido

Low testosterone: 10 quiet signs beyond libido

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Oct 10, 2025 · 16 min read

Low testosterone can show up as a quiet cluster of signs beyond libido, including fewer morning erections, fatigue, increased belly fat, reduced strength, brain fog, low mood, poor sleep, and reduced body hair. Here is how to recognize the full pattern early, what it means medically, and which steps actually move the needle. “Men often ...

How can you save money on long term TRT treatment? The real testosterone cost without insurance

How can you save money on long term TRT treatment? The real testosterone cost without insurance

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Aug 26, 2025 · 15 min read

You can save money on long term TRT treatment by confirming the diagnosis with guideline based testing, choosing a lower cost testosterone delivery method when appropriate, and following an evidence based monitoring schedule instead of paying for unnecessary monthly lab bundles. The biggest savings usually come from transparent itemized pricing, in network or cash discount ...

Understanding testosterone replacement therapy side effects and management

Understanding testosterone replacement therapy side effects and management

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Aug 23, 2025 · 15 min read

In men with confirmed hypogonadism, testosterone replacement therapy can relieve symptoms but can also cause predictable side effects because added testosterone feeds back on the hypothalamic-pituitary-testicular axis and changes downstream markers like blood counts. Many guidelines use total testosterone below about 300 ng/dL on two separate morning tests, interpreted with symptoms and the lab’s reference ...

Evaluating testosterone replacement therapy costs in 2026: What U.S. Men actually pay and how to lower the bill

Evaluating testosterone replacement therapy costs in 2026: What U.S. Men actually pay and how to lower the bill

Dr. Jonathan Pierce, PhD avatar
Dr. Jonathan Pierce, PhD: Clinical Psychologist & Neuroscience Specialist
Aug 23, 2025 · 14 min read

In the U.S., evaluating testosterone replacement therapy costs usually means budgeting about $800 to $7,000+ per year once medication, lab monitoring, and follow up visits are included. The best way to avoid overpaying is to confirm a real testosterone deficiency, pick a delivery method you will actually stick with, and use guideline based monitoring instead ...

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