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All the latest articles from our medical experts on testosterone, men's health, and longevity.

Does creatine cause erectile dysfunction? The evidence says no

Does creatine cause erectile dysfunction? The evidence says no

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Jan 01, 2026 · 9 min read

In healthy adults, creatine monohydrate has not been shown in human studies to cause erectile dysfunction or lower libido. Because creatine’s main job is recycling ATP for muscle energy—and the rumor often comes from confusing kidney-disease–related ED with supplement use—here’s what the evidence supports and what to do if erections change. “When patients ask ‘does ...

Is the male midlife crisis real? The science behind the slump

Is the male midlife crisis real? The science behind the slump

Dr. Jonathan Pierce, PhD avatar
Dr. Jonathan Pierce, PhD: Clinical Psychologist & Neuroscience Specialist
Dec 31, 2025 · 9 min read

A male “midlife crisis” isn’t a DSM-5 diagnosis, but the midlife slump is real: large studies show life satisfaction typically bottoms out around ages 47–48, often colliding with age-related testosterone decline and peak life stress. Here’s what’s happening in the brain and body—and how to navigate the shift with a strategy, not willpower. “We often ...

Peptides vs TRT: Which therapy optimizes male performance and longevity?

Peptides vs TRT: Which therapy optimizes male performance and longevity?

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 31, 2025 · 10 min read

TRT best optimizes male performance when a man has clinically low testosterone (levels decline about 1% per year after age 30) because it replaces missing androgen directly, while growth-hormone secretagogue peptides target recovery and tissue repair by stimulating the pituitary to pulse more of its own HGH—so neither is universally “better” for longevity. Here’s how ...

Can you build muscle in a calorie deficit? The science of body recomposition

Can you build muscle in a calorie deficit? The science of body recomposition

Dr. Bruno Rodriguez, DPT, CSCS avatar
Dr. Bruno Rodriguez, DPT, CSCS: Strength, Recovery, and Physical Therapy Expert
Dec 29, 2025 · 10 min read

Men can build muscle while in a calorie deficit when resistance training drives muscle protein synthesis and the body mobilizes stored fat to subsidize the energy cost of new tissue. The effect is most pronounced in beginners, men returning after a layoff, and those with higher body-fat, but the “margin for error” is small if ...

Seasonal affective disorder or hormones? A men’s guide to winter mood, testosterone, and sleep

Seasonal affective disorder or hormones? A men’s guide to winter mood, testosterone, and sleep

Dr. Susan Carter, MD avatar
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 29, 2025 · 12 min read

In men, winter “low mood” can be true seasonal affective disorder (a recurrent depressive pattern that starts in late fall, peaks in winter, and eases as daylight returns) or a look‑alike driven by physiology—less morning light can delay your circadian rhythm and prolong melatonin, while testosterone, cortisol, and thyroid shifts can produce the same fatigue ...

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