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All the latest articles from our medical experts on testosterone, men's health, and longevity.

Semaglutide and testosterone: The science of combining therapies for men

Semaglutide and testosterone: The science of combining therapies for men

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 08, 2025 · 10 min read

In men with obesity (BMI over 30) and low testosterone, combining semaglutide with testosterone therapy can promote fat loss while helping preserve lean muscle by reducing adipose-driven aromatase conversion of testosterone to estradiol and supporting anabolic metabolism. Instead of treating weight and hormones as separate problems, this paired approach targets the feedback loop where visceral ...

Metformin over the counter: Why it requires a script and how to get one safely

Metformin over the counter: Why it requires a script and how to get one safely

Dr. Susan Carter, MD avatar
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 08, 2025 · 11 min read

Metformin is prescription-only in the U.S., Canada, and the U.K. because it alters mitochondrial energy metabolism and relies on kidney clearance, so reduced renal function can increase the risk of lactic acidosis (dangerously high blood acidity). If you’re pursuing it for weight management or longevity, here’s how clinicians evaluate labs and prescribe it safely through ...

Henry Cavill weight training: The physiology behind the Man of Steel’s physique

Henry Cavill weight training: The physiology behind the Man of Steel’s physique

Dr. Bruno Rodriguez, DPT, CSCS avatar
Dr. Bruno Rodriguez, DPT, CSCS: Strength, Recovery, and Physical Therapy Expert
Dec 07, 2025 · 10 min read

Henry Cavill’s “superhero” build (reportedly ~190–210 lb on screen) is achieved by combining high‑mechanical‑tension lifting to stimulate hypertrophy with metabolic work (including fasted cardio) that increases lipid oxidation, allowing simultaneous muscle gain and fat loss (“recomposition”). Here’s how recovery, neuromuscular adaptation, and joint-protective programming make that body composition sustainable instead of short-lived “ego lifting.” “When ...

What do elliptical trainers do for your physique and longevity?

What do elliptical trainers do for your physique and longevity?

Dr. Bruno Rodriguez, DPT, CSCS avatar
Dr. Bruno Rodriguez, DPT, CSCS: Strength, Recovery, and Physical Therapy Expert
Dec 07, 2025 · 13 min read

Elliptical trainers are more than a backup plan when every treadmill is taken. Here is what they actually do to your muscles, joints, heart, and hormones, and how men can use them for real results. “When guys ask me what do elliptical trainers do, they usually underestimate them. Used with real intent and proper form, ...

The worst foods for gut health and how they disrupt your entire system

The worst foods for gut health and how they disrupt your entire system

Dr. Susan Carter, MD avatar
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 06, 2025 · 9 min read

Ultra-processed foods high in added sugar, artificial sweeteners/additives, and unhealthy fats can shift your microbiome toward dysbiosis in as little as 24 hours, erode the protective mucosal barrier, and let bacterial toxins leak into the bloodstream to fuel systemic inflammation. Here’s the clinical evidence for which foods do the most damage—and how to rebuild a ...

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