XY Files Blog

Evidence-based articles on testosterone, men's health, fitness, longevity, and sexual health.

BPC-157 FDA status in 2026: Compounding ban explained

BPC-157 FDA status in 2026: Compounding ban explained

Susan Carter, MD avatar
Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 03, 2025 · 13 min read

As of February 15, 2026, BPC-157 is not an FDA-approved drug, and it appears on the FDA’s Section 503A “Category 2” bulk drug substances list.[2] In practice, that listing is a major reason routine 503A compounding and dispensing of BPC-157 is generally not permitted, and many licensed compounding pharmacies will not dispense it for routine ...

The science of food noise and how to turn down the volume

The science of food noise and how to turn down the volume

Jonathan Pierce, PhD avatar
Jonathan Pierce, PhD: Clinical Psychologist & Neuroscience Specialist
Dec 03, 2025 · 17 min read

If your brain never shuts up about food, it is not a character flaw. It is a brain-body signal problem that you can dial down with the right mix of habits, hormones and, when needed, medication. “When a man tells me he wakes up thinking about food and goes to bed planning his next snack, ...

Do runners live longer? The science behind mileage and mortality

Do runners live longer? The science behind mileage and mortality

Susan Carter, MD avatar
Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 03, 2025 · 16 min read

In long-term studies, running as little as 5 to 10 minutes a day at an easy pace is linked to roughly a three-year longer lifespan and about a 27% lower risk of all-cause mortality versus not running. The sweet spot for longevity appears to be moderate weekly volume (around 2 to 3 hours), not marathon-level ...

Testosterone killing foods: What actually lowers T in men and what to eat instead

Testosterone killing foods: What actually lowers T in men and what to eat instead

Susan Carter, MD avatar
Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 03, 2025 · 17 min read

“Testosterone killing foods” are foods that, when eaten often as part of an ultra processed Western style diet, are linked to lower testosterone in men through inflammation, insulin disruption, and weight gain. The good news is that you do not need a perfect diet. You need a few high impact swaps and the right lab ...

On Cloud X 3 review: The biomechanics of a true hybrid training shoe

On Cloud X 3 review: The biomechanics of a true hybrid training shoe

Bruno Rodriguez, DPT, CSCS avatar
Bruno Rodriguez, DPT, CSCS: Strength, Recovery, and Physical Therapy Expert
Dec 02, 2025 · 11 min read

The Cloud X 3 functions as a true hybrid only for moderate lifting and short runs (about 1 to 4 miles) by pairing firmer, less-compressible CloudTec foam with a Speedboard to improve force transfer while still attenuating running impacts that can exceed 2.5 times body weight. This evidence-based review breaks down where that stability and ...

Volume eating: The simplest way for men to cut calories without feeling hungry

Volume eating: The simplest way for men to cut calories without feeling hungry

Susan Carter, MD avatar
Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 02, 2025 · 13 min read

Volume eating is a nutrition strategy that emphasizes high volume, low calorie foods so you feel full while naturally eating fewer calories. Done right, it can make fat loss feel less like willpower and more like smart meal design. “Volume eating works best when you treat it as a way to add smart volume, not ...

Dry skin on penis or eczema on the pennis? Causes, symptoms, and fixes

Dry skin on penis or eczema on the pennis? Causes, symptoms, and fixes

Alexander Grant, MD, PhD avatar
Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 02, 2025 · 14 min read

Most cases of dry, flaky, or itchy penile skin are irritant contact dermatitis from barrier breakdown in the penis’ thin stratum corneum (often triggered by friction, sweat, soaps, detergents, or condoms), not an STI. Here’s how to tell simple irritation from eczema, psoriasis, yeast, or balanitis. Here is what actually helps the skin heal. “Most ...

Hot flush in males: Causes, symptoms, and treatments that actually help

Hot flush in males: Causes, symptoms, and treatments that actually help

Alexander Grant, MD, PhD avatar
Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 01, 2025 · 14 min read

A hot flush in males is most often triggered by a meaningful drop in testosterone that disrupts the brain’s temperature control. The good news is that male hot flashes are common, measurable, and usually treatable once you identify the driver. “When a guy tells me he’s getting sudden heat waves and drenching sweat, I think ...

Why no morning wood happens and what it reveals about your vascular health

Why no morning wood happens and what it reveals about your vascular health

Alexander Grant, MD, PhD avatar
Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 01, 2025 · 14 min read

Losing morning erections for many weeks often means nocturnal penile tumescence is being blunted by reduced penile blood flow, impaired nerve signaling, or poor sleep. This can flag vascular problems even when testosterone is normal. Here’s how to interpret the change and when it should prompt a closer look at diabetes and cardiovascular risk. “Morning ...

AI in healthcare and your next doctor visit: How the new medical revolution changes men’s care

AI in healthcare and your next doctor visit: How the new medical revolution changes men’s care

Alexander Grant, MD, PhD avatar
Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 01, 2025 · 11 min read

AI in healthcare is already changing your next doctor visit by automating note taking, speeding up image reads, and turning your labs and wearable data into clearer clinical decisions. The real win is not a robot doctor. It is a more focused conversation, with fewer missed signals in men’s health. “When AI handles the paperwork ...

How quickly does a b12 shot work? A realistic timeline for men

How quickly does a b12 shot work? A realistic timeline for men

Susan Carter, MD avatar
Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 01, 2025 · 15 min read

Vitamin B12 blood levels typically rise within hours to 24 hours after an injection. If symptoms improve, it often occurs over days to weeks, depending on how severe the deficiency is and what is causing your symptoms. If you are not truly B12 deficient or you have another root cause of fatigue, the “boost” may ...

How much does the bar weight bench press: A complete guide to lifting standards

How much does the bar weight bench press: A complete guide to lifting standards

Bruno Rodriguez, DPT, CSCS avatar
Bruno Rodriguez, DPT, CSCS: Strength, Recovery, and Physical Therapy Expert
Nov 30, 2025 · 15 min read

How much does a bench press bar weigh? A complete guide to barbell standards A standard Olympic barbell used for the bench press weighs 45 lb (20 kg) before you add any plates. From there, your “real” bench number is the total loaded weight, and a common general-fitness target is about a 1:1 bench-to-bodyweight ratio ...

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