Sexual health

Start with what matters: desire, function, and comfort. We explain libido, arousal, erectile function, orgasm, and sexual pain, and how medicines and hormones influence them. Clear language, evidence-based guidance, and practical steps to understand your body and improve sexual well-being.

Estrogen in men: Low Estradiol can ruin your TRT therapy

Estrogen in men: Low Estradiol can ruin your TRT therapy

Dr. Susan Carter, MD avatar
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Oct 26, 2025 · 13 min read

Low estradiol can derail TRT even when testosterone looks “normal,” because aromatase converts testosterone into estradiol and symptoms often appear when estradiol falls below about 20 pg/mL. Learn the key signs, the right lab test to order, and how to fix low E2 without crashing your hormones. “Men often think estrogen is the enemy, but ...

Low libido: When the brain is the issue

Low libido: When the brain is the issue

Dr. Jonathan Pierce, PhD avatar
Dr. Jonathan Pierce, PhD: Clinical Psychologist & Neuroscience Specialist
Oct 19, 2025 · 15 min read

Low libido in men is often a brain-and-life issue: changes in reward and stress signaling (including dopamine- and norepinephrine-driven “wanting”) can lower sexual desire for weeks or months even when testosterone is normal. About 15–25% of men report reduced desire at some point—here’s how mood, stress, medications, hormones, and daily habits interact, and what actually ...

Low testosterone: 10 quiet signs beyond libido

Low testosterone: 10 quiet signs beyond libido

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Oct 10, 2025 · 15 min read

Low testosterone 10 quiet signs often creep in so slowly that men blame age, stress, or weight gain. Here is how to recognize the full pattern early, what it means medically, and which steps actually move the needle. “Men often assume low testosterone is only about sex drive, but the body rarely sends just one ...

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