
Understanding testosterone replacement therapy: Potential risks and benefits

Men with clear hypogonadal symptoms and confirmed low testosterone (about total
Dr. Susan Carter is an endocrinologist and longevity expert specializing in hormone balance, metabolism, and the aging process. She links low testosterone with thyroid and cortisol patterns and turns lab data into clear next steps. Patients appreciate her straightforward approach, preventive mindset, and calm, data-driven care.


Men with clear hypogonadal symptoms and confirmed low testosterone (about total


In men with confirmed hypogonadism (total testosterone below ~350 ng/dL or free testosterone below ~100 pg/mL), properly monitored TRT hasn’t shown a major rise in heart attack or stroke risk in recent trials, but it can increase hematocrit by stimulating red blood cell production and may worsen prostate symptoms or suppress fertility over time. Here’s ...


TRT is most likely to be “worth it” for men with persistent symptoms and confirmed low testosterone (total testosterone below ~350 ng/dL or free testosterone below ~100 pg/mL) because this group is the most likely to see meaningful clinical benefits when appropriately monitored. The catch is that TRT is usually a multi‑year (sometimes lifelong) commitment ...