Testosterone replacement therapy

Articles covering the basics of TRT, including who it’s for, how it works, common protocols, expected benefits, and potential side effects. Learn how to optimize hormones safely to improve energy, body composition, libido, and long-term health.

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Joe Rogan’s 2025 stack: Onnit creatine 5g, what science says

Joe Rogan’s 2025 stack: Onnit creatine 5g, what science says

Dr. Bruno Rodriguez, DPT, CSCS avatar
Dr. Bruno Rodriguez, DPT, CSCS: Strength, Recovery, and Physical Therapy Expert
Dec 30, 2025 · 10 min read

Creatine monohydrate is the most consistently performance-boosting supplement in Rogan’s stack because it raises muscle phosphocreatine to regenerate ATP during high-intensity training, while most OTC “testosterone boosters” and trendy biohacks are largely hype without a true deficiency or prescription therapy. Rogan has also talked about keeping it simple with “5 grams” of creatine per day, ...

Does testosterone increase metabolism in men?

Does testosterone increase metabolism in men?

Dr. Susan Carter, MD avatar
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 09, 2025 · 12 min read

In men with confirmed testosterone deficiency, testosterone replacement can modestly increase metabolic rate over 6–12 months, largely by adding lean muscle (which raises basal metabolic rate) and reducing visceral fat. The biggest payoff shows up when strength training, protein intake, and sleep are dialed in—and men with normal levels usually see little metabolic benefit while ...

Semaglutide and testosterone: The science of combining therapies for men

Semaglutide and testosterone: The science of combining therapies for men

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 08, 2025 · 10 min read

In men with obesity (BMI over 30) and low testosterone, combining semaglutide with testosterone therapy can promote fat loss while helping preserve lean muscle by reducing adipose-driven aromatase conversion of testosterone to estradiol and supporting anabolic metabolism. Instead of treating weight and hormones as separate problems, this paired approach targets the feedback loop where visceral ...

TRT before and after: What the clinical data actually promises for your body

TRT before and after: What the clinical data actually promises for your body

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 04, 2025 · 13 min read

In men with symptoms and consistently low testosterone (total testosterone under ~350 ng/dL, or free testosterone under ~100 pg/mL), TRT that restores levels to the mid‑normal range (~400–700 ng/dL) can increase lean muscle, reduce fat mass, and improve sexual function, with modest improvements in mood and vitality. The viral “before and after” transformations are often ...

How long does it take for testosterone to work? A clinical timeline for results

How long does it take for testosterone to work? A clinical timeline for results

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Nov 29, 2025 · 13 min read

In clinical trials of TRT for hypogonadism, libido, energy, and mood often improve within about 3–6 weeks, while erection quality and muscle/fat changes typically take 12–16 weeks and bone benefits start around 6 months. Because different tissues respond on different timelines, this guide shows what to expect month by month — and how regular 3‑month ...

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