Low testosterone

Covers the causes, symptoms, and health impacts of low testosterone, from low libido and fatigue to reduced muscle mass and mood changes. Learn how to assess testosterone properly with labs, improve it through lifestyle and nutrition, and understand when TRT or other medical options may be appropriate.

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The essentials for low testosterone — then explore the latest posts below.

Does alcohol cause inflammation? What men need to know about the immune response

Does alcohol cause inflammation? What men need to know about the immune response

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Jan 04, 2026 · 10 min read

Alcohol causes systemic, dose-dependent inflammation by producing acetaldehyde and activating liver immune cells (Kupffer cells) to release pro-inflammatory cytokines such as TNF-α and IL-6, while also weakening the gut barrier so bacterial toxins can enter the bloodstream. That immune “alarm” can keep firing long after the buzz fades—affecting blood vessels, testosterone production, and sexual function. ...

Semaglutide and testosterone: The science of combining therapies for men

Semaglutide and testosterone: The science of combining therapies for men

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 08, 2025 · 10 min read

In men with obesity (BMI over 30) and low testosterone, combining semaglutide with testosterone therapy can promote fat loss while helping preserve lean muscle by reducing adipose-driven aromatase conversion of testosterone to estradiol and supporting anabolic metabolism. Instead of treating weight and hormones as separate problems, this paired approach targets the feedback loop where visceral ...

Can low testosterone cause joint pain?

Can low testosterone cause joint pain?

Dr. Susan Carter, MD avatar
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 06, 2025 · 13 min read

Low testosterone can contribute to joint pain by increasing chronic inflammation and weakening the muscle, bone, and cartilage support that stabilizes joints, and studies have linked low levels to about double the risk of developing osteoarthritis. If aching knees or stiff shoulders come with fatigue, lower libido, or shrinking strength, it’s worth seeing how hormones ...

Does stress cause low testosterone in men? What science really shows

Does stress cause low testosterone in men? What science really shows

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 05, 2025 · 14 min read

Chronic psychological stress is linked to lower morning testosterone in men, largely because sustained HPA-axis cortisol output can suppress hypothalamic–pituitary–gonadal (GnRH/LH) signaling and reduce testicular testosterone production. Here’s how to recognize the stress–low T feedback loop and what actually helps break it. “Stress and testosterone talk to each other all day long. Short bursts of ...

Top 3 ways to increase testosterone naturally

Top 3 ways to increase testosterone naturally

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Oct 30, 2025 · 11 min read

The most reliable natural ways to raise testosterone in men are to reduce abdominal fat (losing ~10% of body weight typically increases total testosterone by ~80–100 ng/dL, and ~15% can add ~200–250 ng/dL), prioritize consistent sleep, and lower chronic stress that suppresses the brain–testicle (HPT) axis. Here’s how to apply those levers safely, what “low ...

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