Fertility and testosterone

Covers how natural testosterone levels and testosterone therapy can impact male fertility, including sperm production, hormones, and family planning. Learn strategies to protect or restore fertility while optimizing testosterone for health, performance, and long-term wellbeing.

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The essentials for fertility and testosterone — then explore the latest posts below.

TRT side effects. Facts and myths.

TRT side effects. Facts and myths.

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Nov 14, 2025 · 13 min read

Testosterone replacement can change energy, mood, strength, and sex drive — but it also shifts blood, skin, fertility, and prostate health. Here is a clear, evidence-based guide to TRT side effects and how to manage them safely. “Most problems blamed on TRT are preventable. The real risk is starting testosterone in the wrong man, at ...

5 testosterone side effects you must be aware of

5 testosterone side effects you must be aware of

Dr. Susan Carter, MD avatar
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Oct 14, 2025 · 15 min read

Testosterone replacement commonly causes a 2–5 mmHg rise in blood pressure, can thicken blood via erythrocytosis (hematocrit may climb to ≥54%), may suppress sperm production and fertility, can increase oily skin/acne, and can worsen obstructive sleep apnea. Tracking blood pressure, hematocrit, and symptoms from day one helps you and your clinician adjust dose or formulation ...

Enclomiphene: Double testosterone without injections

Enclomiphene: Double testosterone without injections

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Oct 12, 2025 · 12 min read

In randomized trials of men with functional hypogonadism, daily enclomiphene (a SERM) blocks estrogen feedback in the hypothalamus and pituitary to raise LH/FSH and increase morning testosterone into or near the normal range—sometimes roughly doubling very low baseline levels—while sperm counts stayed largely stable. Here’s who is most likely to benefit, what to monitor, and ...

Unexpected effects of testosterone therapy you should know

Unexpected effects of testosterone therapy you should know

Dr. Susan Carter, MD avatar
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Aug 23, 2025 · 15 min read

Testosterone therapy can cause “unexpected” side effects beyond libido and muscle gains, including bone-marrow–driven rises in hemoglobin/hematocrit that can reach erythrocytosis when hematocrit exceeds ~54%, along with water retention, acne, mood changes, and reduced fertility. Here’s what to monitor, why these effects happen, and how to manage them safely with your clinician. “Testosterone can be ...

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