Episode 1: Facing the truth: My experience with testosterone replacement therapy side effects
January 19, 2026 · 10:42
Evidence-based look at TRT side effects and the monitoring steps needed to manage them safely.
TRT and fertility
Covers how testosterone replacement therapy can affect sperm production, testicular function, and overall fertility, plus what to expect on labs and symptoms. Learn evidence-based strategies men use to preserve or restore fertility while optimizing hormones, performance, and long-term health.
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What you need to know about testosterone replacement therapy risks
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Aug 07, 2025 · 14 min read
In men with confirmed hypogonadism (total testosterone below ~350 ng/dL or free testosterone below ~100 pg/mL), properly monitored TRT hasn’t shown a major rise in heart attack or stroke risk in recent trials, but it can increase hematocrit by stimulating red blood cell production and may worsen prostate symptoms or suppress fertility over time. Here’s ...
Facing the truth: My experience with testosterone replacement therapy side effects
Dr. Bruno Rodriguez, DPT, CSCS: Strength, Recovery, and Physical Therapy Expert
Aug 06, 2025 · 12 min read
Testosterone replacement therapy can cause predictable side effects—most notably testosterone-driven increases in red blood cell production that push hematocrit above 54% in about 18–20% of men, a threshold linked to thicker blood and higher clot/cardiovascular risk when not monitored. Here’s how the main risks (blood, fluid retention, hair/skin changes, and hormone shutdown) happen and what ...