What you need to know about testosterone replacement therapy risks
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Aug 07, 2025 · 14 min read
In men with confirmed hypogonadism (total testosterone below ~350 ng/dL or free testosterone below ~100 pg/mL), properly monitored TRT hasn’t shown a major rise in heart attack or stroke risk in recent trials, but it can increase hematocrit by stimulating red blood cell production and may worsen prostate symptoms or suppress fertility over time. Here’s ...