Testosterone therapy

Covers the basics of testosterone therapy (including TRT), who it may help, and how it can impact energy, libido, mood, muscle, and body composition. Learn about benefits, risks, side effects, and key labs to monitor so you can optimize treatment safely for long-term health and performance.

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The essentials for testosterone therapy — then explore the latest posts below.

Does TRT raise blood pressure? What the science says

Does TRT raise blood pressure? What the science says

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 15, 2025 · 10 min read

In a 2023 New England Journal of Medicine trial of over 5,000 men, testosterone replacement therapy did not increase major cardiovascular events, although some individuals can develop modest systolic blood pressure increases from fluid shifts and higher blood viscosity. Here’s how dose, baseline metabolic health, and careful monitoring help “optimize” testosterone without pushing blood pressure ...

How long does it take for testosterone to work? A clinical timeline for results

How long does it take for testosterone to work? A clinical timeline for results

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Nov 29, 2025 · 13 min read

In clinical trials of TRT for hypogonadism, libido, energy, and mood often improve within about 3–6 weeks, while erection quality and muscle/fat changes typically take 12–16 weeks and bone benefits start around 6 months. Because different tissues respond on different timelines, this guide shows what to expect month by month — and how regular 3‑month ...

Top 3 ways to increase testosterone naturally

Top 3 ways to increase testosterone naturally

Dr. Alexander Grant, MD, PhD avatar
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Oct 30, 2025 · 11 min read

The most reliable natural ways to raise testosterone in men are to reduce abdominal fat (losing ~10% of body weight typically increases total testosterone by ~80–100 ng/dL, and ~15% can add ~200–250 ng/dL), prioritize consistent sleep, and lower chronic stress that suppresses the brain–testicle (HPT) axis. Here’s how to apply those levers safely, what “low ...

Is testosterone replacement therapy cost worth it for us?

Is testosterone replacement therapy cost worth it for us?

Dr. Susan Carter, MD avatar
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Aug 06, 2025 · 12 min read

TRT is most likely to be “worth it” for men with persistent symptoms and confirmed low testosterone (total testosterone below ~350 ng/dL or free testosterone below ~100 pg/mL) because this group is the most likely to see meaningful clinical benefits when appropriately monitored. The catch is that TRT is usually a multi‑year (sometimes lifelong) commitment ...

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