Testosterone side effects

Covers potential side effects of testosterone and TRT, from acne and water retention to changes in mood, fertility, and blood markers like hematocrit. Learn what’s normal, what’s a red flag, and how to manage risks safely while optimizing performance and long-term health.

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The essentials for testosterone side effects — then explore the latest posts below.

Bioidentical hormone replacement therapy for men: Science, safety, and real-world results

Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate

Nov 28, 2025 · 14 min read

Most prescription testosterone replacement used in men is already “bioidentical” — the hormone molecule is chemically identical to what the testes produce, even as levels commonly decline about 1% per year after age 30–40. The real question is whether you have symptomatic, consistently low testosterone and how to dose and monitor therapy to restore a ...

5 testosterone side effects you must be aware of

Dr. Susan Carter, MD: Endocrinologist & Longevity Expert

Oct 14, 2025 · 15 min read

Testosterone replacement commonly causes a 2–5 mmHg rise in blood pressure, can thicken blood via erythrocytosis (hematocrit may climb to ≥54%), may suppress sperm production and fertility, can increase oily skin/acne, and can worsen obstructive sleep apnea. Tracking blood pressure, hematocrit, and symptoms from day one helps you and your clinician adjust dose or formulation ...