Episode 1: Facing the truth: My experience with testosterone replacement therapy side effects
January 19, 2026 · 10:42
Evidence-based look at TRT side effects and the monitoring steps needed to manage them safely.
Testosterone replacement therapy side effects
Covers the most common and less common side effects of TRT, including changes in hematocrit, acne, mood, fertility, and cardiovascular risk markers. Helps men understand what to watch for, how to reduce risks, and when to adjust dose, protocol, or monitoring for better health and performance.
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How testosterone replacement therapy injections can boost your mood
Dr. Jonathan Pierce, PhD: Clinical Psychologist & Neuroscience Specialist
Aug 08, 2025 · 12 min read
In men with symptomatic hypogonadism (total testosterone below about 350 ng/dL), testosterone injections that restore levels to the mid‑normal range can modestly improve mood and vitality by increasing androgen signaling in brain reward and emotional‑balance circuits. Here’s who’s most likely to benefit, how the shots release hormone over days, and why they’re not a cure‑all. ...
Facing the truth: My experience with testosterone replacement therapy side effects
Dr. Bruno Rodriguez, DPT, CSCS: Strength, Recovery, and Physical Therapy Expert
Aug 06, 2025 · 12 min read
Testosterone replacement therapy can cause predictable side effects—most notably testosterone-driven increases in red blood cell production that push hematocrit above 54% in about 18–20% of men, a threshold linked to thicker blood and higher clot/cardiovascular risk when not monitored. Here’s how the main risks (blood, fluid retention, hair/skin changes, and hormone shutdown) happen and what ...