Understanding testosterone replacement therapy side effects and management
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Aug 23, 2025 · 15 min read
In men with confirmed hypogonadism, testosterone replacement therapy can relieve symptoms but can also cause predictable side effects because added testosterone feeds back on the hypothalamic-pituitary-testicular axis and changes downstream markers like blood counts. Many guidelines use total testosterone below about 300 ng/dL on two separate morning tests, interpreted with symptoms and the lab’s reference ...