Testosterone and mood

Covers how testosterone levels can influence mood, stress resilience, motivation, and overall mental well-being in men. Explains what symptoms may signal hormonal imbalance and how training, sleep, lifestyle, and TRT can impact mood and performance.

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The essentials for testosterone and mood — then explore the latest posts below.

Unexpected effects of testosterone therapy you should know

Dr. Susan Carter, MD: Endocrinologist & Longevity Expert

Aug 23, 2025 · 15 min read

Testosterone therapy can cause “unexpected” side effects beyond libido and muscle gains, including bone-marrow–driven rises in hemoglobin/hematocrit that can reach erythrocytosis when hematocrit exceeds ~54%, along with water retention, acne, mood changes, and reduced fertility. Here’s what to monitor, why these effects happen, and how to manage them safely with your clinician. “Testosterone can be ...

How testosterone replacement therapy injections can boost your mood

Dr. Jonathan Pierce, PhD: Clinical Psychologist & Neuroscience Specialist

Aug 08, 2025 · 12 min read

In men with symptomatic hypogonadism (total testosterone below about 350 ng/dL), testosterone injections that restore levels to the mid‑normal range can modestly improve mood and vitality by increasing androgen signaling in brain reward and emotional‑balance circuits. Here’s who’s most likely to benefit, how the shots release hormone over days, and why they’re not a cure‑all. ...