Semaglutide and testosterone: The science of combining therapies for men
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 08, 2025 · 10 min read
In men with obesity (BMI over 30) and low testosterone, combining semaglutide with testosterone therapy can promote fat loss while helping preserve lean muscle by reducing adipose-driven aromatase conversion of testosterone to estradiol and supporting anabolic metabolism. Instead of treating weight and hormones as separate problems, this paired approach targets the feedback loop where visceral ...