Can low testosterone cause joint pain?
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 06, 2025 · 15 min read
Low testosterone can contribute to joint pain by increasing chronic inflammation and weakening the muscle, bone, and cartilage support that stabilizes joints. A 2025 longitudinal cohort study in BMC Musculoskeletal Disorders reported that men with low testosterone had about double the risk of developing osteoarthritis. [4] If aching knees or stiff shoulders come with fatigue, ...