How to lower hematocrit on trt safely and effectively
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 11, 2025 · 10 min read
The safest way to lower hematocrit on TRT is to reduce testosterone peaks—by lowering the dose and/or switching from infrequent injections to more frequent micro-dosing or a steadier transdermal method—because testosterone increases red blood cell production through kidney-driven erythropoietin (EPO) signaling. Since elevated hematocrit affects roughly 5% to 66% of men on therapy, the goal ...