Does TRT raise blood pressure? What the science says
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 15, 2025 · 10 min read
In a 2023 New England Journal of Medicine trial of over 5,000 men, testosterone replacement therapy did not increase major cardiovascular events, although some individuals can develop modest systolic blood pressure increases from fluid shifts and higher blood viscosity. Here’s how dose, baseline metabolic health, and careful monitoring help “optimize” testosterone without pushing blood pressure ...