
Estrogen in men: Low Estradiol can ruin your TRT therapy

Susan Carter, MD: Endocrinologist & Longevity expert
Oct 26, 2025 · 13 min read
Low estradiol in men is common, especially on testosterone therapy, and can quietly drain libido, mood, and bone strength. Here is how to recognize low estradiol, get the right tests, and correct it without crashing your hormones. “Men often think estrogen is the enemy, but low estradiol in men is just as harmful as high […]