The science of supplements: Which vitamins actually fight male fatigue?
Dr. Susan Carter, MD: Endocrinologist & Longevity Expert
Dec 18, 2025 · 12 min read
In men with low or marginal levels, repleting key energy cofactors can reduce fatigue by supporting mitochondrial ATP production and stabilizing testosterone-related energy pathways. These include B vitamins (especially B12, folate, and B6), vitamin D, and zinc. Here’s how to spot the signals, confirm them with the right labs, and target what’s actually limiting your ...