Enclomiphene: Double testosterone without injections
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Oct 12, 2025 · 12 min read
In randomized trials of men with functional hypogonadism, daily enclomiphene (a SERM) blocks estrogen feedback in the hypothalamus and pituitary to raise LH/FSH and increase morning testosterone into or near the normal range—sometimes roughly doubling very low baseline levels—while sperm counts stayed largely stable. Here’s who is most likely to benefit, what to monitor, and ...