
Low libido: When the brain is the issue

Dr. Jonathan Pierce, PhD: Clinical Psychologist & Neuroscience Specialist
Oct 19, 2025 · 16 min read
Low libido in men is often a brain-and-life issue. Changes in reward and stress signaling (including dopamine- and norepinephrine-driven “wanting”) can lower sexual desire for weeks or months even when testosterone is normal. About 15–25% of men report reduced desire at some point. Here’s how mood, stress, medications, hormones, and daily habits interact, and what ...