Rectal delivery systems: Understanding the clinical role of suppositories in men’s health
Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate
Dec 05, 2025 · 12 min read
Rectal suppositories deliver medication through the highly vascular rectal mucosa, partially bypassing first‑pass liver metabolism so some drugs (such as anti‑inflammatories) can reach effective levels within 30–60 minutes while targeting pelvic tissues with fewer stomach side effects than oral pills. Here’s when they’re clinically useful for men (constipation, hemorrhoids, pelvic/prostate pain, even certain erectile treatments) ...