Bioidentical hormone replacement therapy for men

Sex hormone binding globulin and testosterone in men: What your SHBG levels really mean

Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate

Dec 09, 2025 · 13 min read

SHBG is a liver-made carrier protein that tightly binds roughly 70% of circulating testosterone, so higher SHBG can lower free (bioavailable) testosterone and cause “low T” symptoms even when total testosterone looks normal; adult men typically fall around 13.3–89.5 nmol/L. Understanding where your SHBG sits helps explain what your tissues can actually use—and why treatment ...

Can low testosterone cause joint pain?

Dr. Susan Carter, MD: Endocrinologist & Longevity Expert

Dec 06, 2025 · 13 min read

Low testosterone can contribute to joint pain by increasing chronic inflammation and weakening the muscle, bone, and cartilage support that stabilizes joints, and studies have linked low levels to about double the risk of developing osteoarthritis. If aching knees or stiff shoulders come with fatigue, lower libido, or shrinking strength, it’s worth seeing how hormones ...

TRT before and after: What the clinical data actually promises for your body

Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate

Dec 04, 2025 · 13 min read

In men with symptoms and consistently low testosterone (total testosterone under ~350 ng/dL, or free testosterone under ~100 pg/mL), TRT that restores levels to the mid‑normal range (~400–700 ng/dL) can increase lean muscle, reduce fat mass, and improve sexual function, with modest improvements in mood and vitality. The viral “before and after” transformations are often ...

How long does it take for testosterone to work? A clinical timeline for results

Dr. Alexander Grant, MD, PhD: Urologist & Men's Health Advocate

Nov 29, 2025 · 13 min read

In clinical trials of TRT for hypogonadism, libido, energy, and mood often improve within about 3–6 weeks, while erection quality and muscle/fat changes typically take 12–16 weeks and bone benefits start around 6 months. Because different tissues respond on different timelines, this guide shows what to expect month by month — and how regular 3‑month ...